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Since alcohol is a strong depressant that slows brain function and depresses respiration, the two substances compound each other's actions and this combination can prove fatal.The long-term use of benzodiazepines may have a similar effect on the brain as alcohol, and are also implicated in depression, anxiety, posttraumatic stress disorder (PTSD), mania, psychosis, sleep disorders, sexual dysfunction, delirium, and neurocognitive disorders (including benzodiazepine-induced persisting dementia which persists even after the medications are stopped).In the event of an overdose or if combined with another sedative, many of these drugs can cause unconsciousness (see hypnotic) and even death.

Sedatives can sometimes leave the patient with long-term or short-term amnesia.Barbiturate overdose is a factor in nearly one-third of all reported drug-related deaths.These include suicides and accidental drug poisonings.The paradoxical reactions may consist of depression, with or without suicidal tendencies, phobias, aggressiveness, violent behavior and symptoms sometimes misdiagnosed as psychosis.Sedatives and alcohol are sometimes combined recreationally or carelessly.Both physical and psychological dependence can be treated with therapy.

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